Endocrine Abstracts

Introduction: Resistance to thyroid hormone (RTH), a syndrome reduced end-organ responsiveness to thyroid hormone.Case report: A 42 year old woman underwent near total thyroidectomy due to her enlarged thyroid with multiple nodules. At that time she had sligthly elevated values of plasma FT4, FT3 and normal TSH values and had no sign and symptoms of thyrotoxicosis or hypothyroidism. After thyroidectomy she recieved L-T4 treatment but her TSH levels remai...

Background: Congenital adrenal hyperplasia (CAH) resulting from 17 α hyroxylase enzyme deficiency (17OHD) is a rare autosomal recessive disorder. More than 150 cases were reported in the literature. Patients with 17OHD were reported to have hypoaldosteronism.Case: A 16-year-old female referred to endocrinology outpatient clinic from family medicine department with the absence of a secondary sexual characteristics and primary amenorrhea. On physical ...

Background and Aim: Prolactinoma is the most common type of functional pituitary tumor in adults. Giant prolactinomas are defined as tumors achieve a diameter >4 cm and often have very high serum prolactin level. In our previous study showed that endoscopic endonasal pituitary surgery is a very convenient procedure for the patient due to low morbidity and high efficiency. In this study we evaluated endoscopic endonasal pituitary surgery series in patients with prolactinoma...

Objectives: Hypogonadism is associated with a higher risk of atherosclerosis and cardiovascular disease, but the mechanisms underlying this association are not yet fully understood. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. We aimed to determine serum PON1 activities, an established lipid antioxidant, MDA levels which are end products of lipid peroxidation induced by ROS and thiol groups as an antioxidant fo...

Objective: GH deficiency is associated with an increased cardiovascular mortality. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. In the present study, we aimed to determine i) serum PON1 activities, an established lipid antioxidant, ii) MDA levels which are end products of lipid peroxidation induced by ROS and iii) thiol groups as an antioxidant for evaluating oxidative stress in patients with GHD before and aft...

Introduction: We have reported a case of breast carcinoma complicated by diabetes insipidus due to pituitary metastasis.Case: A 47 years old woman had been referred our clinic with the symptoms of polyuria, polydypsia, weight loss, and fatigue. She had a diagnosis of breast carcinoma for six years, underwent radically mastectomy, chemotherapy and radiotherapy, subsequently. Vertebral metastasis was detected and local radiotherapy was performed six months...

Idiopathic granulomatoushypophysitis is a rare inflammatory disease which is characterized by inflammation and cellular infiltration of the pituitary gland. The infiltration may cause pituitary insufficiency, compression symptoms due to mass effect and diabetes insipidus. We report the case of a 33-year-old female patient who presenting with weakness, fatigue, amenorrhea and worsening of headaches about 3 months. The patient did not have blurring vision and polyuria-polydipsia...

Objectives: T helper1 (Th1) cells were determined to have important roles in the development of type 2 diabetes (T2D). We aimed to investigate relationship between Th1 cytokines (IFN γ, IL-2 and TNF-α) and T2D.Material and methods: The study included 32 newly diagnosed type 2 diabetic patients (T2DPs) who had not begun to take antidiabetic agents except from insulin and 30 healthy subjects (CG) who did not have glucose intoerance (fasting or af...

Introduction: Diabetes mellitus (DM) is an endocrine disease characterised by metabolic abnormalities and long-term complications. Achilles tendon (AT) play an important role in foot biomechanics. We aimed to investigate the effect of DM on the AT, which may contribute to the long-term complications in the foot–ankle complex.Materials and methods: 78 diabetic patients with (35 cases) or without (43 cases) diabetic foot ulcers were recruited from End...

Introduction: Since bariatric surgery is considered to be a more effective treatment modality for morbid obesity, a growing number of patients have been referred to endocrinology clinics in order to exclude an underlying cause. Routine preoperative testing to screen Cushing’s syndrome (CS) or hypothyroidism is still debatable. The aim of this study is to evaluate the accuracy of routine testing in preoperative endocrinological evaluation.Methods/des...